This is a prospective longitudinal cohort study to evaluate the impact of COVID-19 vaccination and booster on maternal and infant immunity against COVID-19 variants over time.
We will enroll 100 pregnant patients who have received COVID-19 mRNA booster as well as 100 breastfeeding patients who have received COVID-19 mRNA booster. Participants will be following longitudinally through 3 months post partum, or 3 months post enrollment for those in the breastfeeding cohort. Maternal blood will be collected, as will cordblood at delivery, breastmilk, and infant samples.
Study Type
OBSERVATIONAL
Enrollment
150
Bivalent COVID-19 Booster by Pfizer or Moderna
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Maternal Serological Profile
Quantitative Maternal IgG to SARS CoV2 spike and other domains
Time frame: 3 months
Maternal Functional Immunity
Quantitative Antibody neutralization capacity
Time frame: 3 months
Infant serological profile
Quantitative IgG to SARS CoV2
Time frame: 3 months old
Infant functional immunity
Quantitative Antibody neutralization capacity
Time frame: 3 months old
Breastmilk serological profile
Quantitative IgA to SARS CoV2
Time frame: 3 months
Infant oral immunity
Quantitative Salivary SARS CoV2 IgG
Time frame: 3 months
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