NCT05545046 - Predictive Model for Pain After TACE | Crick

Overview

The main aim of this study was to analyze the risk factors that helped to predict the pain after transarterial chemoembolization (TACE).This was a prospective observational study enrolled all hepatocellular carcinoma (HCC) patients undergoing TACE in our hospital. Pain score at rest was assessed after TACE by the patients themselves using a Visual Analogue Scale (VAS). Independent variables such as age, gender, tumor location, tumor size and number, drug delivery method and presence of portal vein tumor thrombosis (PVTT) were recorded and analyzed.

Study Type

OBSERVATIONAL

Enrollment

228

Conditions

Hepatocellular Carcinoma

Eligibility

Sex: ALLMin age: 34 YearsMax age: 87 Years

Medical Language ↔ Plain English

Inclusion Criteria: * A diagnosis of HCC was confirmed either histologically or based on consistent findings obtained from at least two imaging techniques. Exclusion Criteria: * patients aged \< 18 year * significant heart or lung dysfunction * use of additional analgesics to relieve pain during TACE * cognitive impairment * use of psychiatric medications * drug or alcohol abuse

Locations (1)

Yuhuangding Hospital

Yantai, Shandong, China

Outcomes

Primary Outcomes

Visual Analogue Scale (VAS)

After local anesthesia with an injection of 10 mL of 2% lidocaine, all the patients enrolled in this study received percutaneous femoral artery puncture. An arterial catheter was inserted into the femoral artery and subsequently placed in the hepatic artery. Then, a conventional TACE or a DEB-TACE procedure was performed. After TACE, all patients received supportive treatment including antiemetics, liver protection, non-steroidal anti-inflammatory drugs.

Time frame: 0 hour after TACE by the patients themselves using a Visual Analogue Scale (VAS)

Visual Analogue Scale (VAS)

After local anesthesia with an injection of 10 mL of 2% lidocaine, all the patients enrolled in this study received percutaneous femoral artery puncture. An arterial catheter was inserted into the femoral artery and subsequently placed in the hepatic artery. Then, a conventional TACE or a DEB-TACE procedure was performed. After TACE, all patients received supportive treatment including antiemetics, liver protection, non-steroidal anti-inflammatory drugs.

Time frame: 2 hour after TACE by the patients themselves using a Visual Analogue Scale (VAS)

Visual Analogue Scale (VAS)

After local anesthesia with an injection of 10 mL of 2% lidocaine, all the patients enrolled in this study received percutaneous femoral artery puncture. An arterial catheter was inserted into the femoral artery and subsequently placed in the hepatic artery. Then, a conventional TACE or a DEB-TACE procedure was performed. After TACE, all patients received supportive treatment including antiemetics, liver protection, non-steroidal anti-inflammatory drugs.

Time frame: 4 hour after TACE by the patients themselves using a Visual Analogue Scale (VAS)

Visual Analogue Scale (VAS)

After local anesthesia with an injection of 10 mL of 2% lidocaine, all the patients enrolled in this study received percutaneous femoral artery puncture. An arterial catheter was inserted into the femoral artery and subsequently placed in the hepatic artery. Then, a conventional TACE or a DEB-TACE procedure was performed. After TACE, all patients received supportive treatment including antiemetics, liver protection, non-steroidal anti-inflammatory drugs.