This study is a single-center, randomized, controlled prospective study. Those who will recieve hormone replacement therapy-frozen thawed embryo transfer (HRT-FET) are enrolled in the study. To determine the effect of oestrogen dosage reducion on maternal and fetal complications in HRT-FET cycles while maintaining the similar clinical pregnancy outcome in HRT-FET cycles with regular oestrogen dosage.
According to the enrollment and exclusion criteria, the patients were enrolled, and the subjects were randomly divided into two groups by computer randomization. Group A was the reduced oestrogen dosage group (test group). Group B was the regular hormone replacement group (control group).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
660
From the second day of the menstrual cycle, femoston (estradiol tablets) were orally taken 2 mg q.d.. The endometrial thickness and serum oestrogen and progesterone levels were monitored on the 12th to 14th days of the menstrual cycle.
Reproductive Medicine Center, The affiliated Drum Towel Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China
RECRUITINGClinical pregnancy rate
Clinical pregnancy is defined as the presence of gestational sac observed by ultrasound. The proportion of clinical pregnancy cycles to total FET cycles is the clinical pregnancy rate.
Time frame: 45 days after embryo transfer
Embryo implantation rate
The proportion of the number of implanted embryos to the total number of transferred embryos is the embryo implantation rate.
Time frame: 45 days after embryo transfer
Early pregnancy loss rate
The early pregnancy loss rate refers to the proportion of patients with pregnancy loss before 12 weeks of gestation in the total clinical pregnancy patients.
Time frame: 12 weeks after embryo transfer
Incidence of thrombosis
Thrombosis incidence refers to the proportion of patients with deep venous thrombosis in the total patients.
Time frame: 12 weeks after embryo transfer
Incidence rate of gestational hypertension
The incidence rate of gestational hypertension refers to the proportion of patients with gestational hypertension in the total pregnant patients.
Time frame: 45 weeks after embryo transfer
Premature birth rate
Preterm birth rate refers to the proportion of patients with preterm birth in all pregnancies.
Time frame: 41 weeks after embryo transfer
Proportion of low birth weight infants
The proportion of low birth weight infants refers to the proportion of low birth weight infants in all newborns.
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Time frame: 41 weeks after embryo transfer