Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting

Inclusion Criteria: * (PHQ\>8) if depressed * Subjects of any sex aged between 18-70 * Sufficient ability to speak and understand the german language * Ability to understand and sign the informed consent form Exclusion Criteria: * Cognitive impairment that interferes with reliable completion of questionnaires or answering questions * Presence of manic episode, bipolar disorder, Schizophrenia or schizoaffective disorder (as well as other diseases in the F2 domain in the ICD), active eating disorder, active drug or alcohol dependence syndrome * Presence of uncontrolled systemic disease (e.g. autoimmune disease), uncontrolles somatic (other than metabolic or cardiovascular)/ neurologic diseases, current or recent (last month) physical trauma * Patient with acute suicidal ideation * known deficiency of alpha-1-antitrypsin * pregnant or lactating women