This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.MCP-1, IL-8, oxLDL, TNF-α will be tested for concentration using ELISA.
Study Type
OBSERVATIONAL
Enrollment
64
supragingival scaling,subgingival scaling
2nd Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
RECRUITINGmonocyte chemotactic protein-1，MCP-1
Concentration of MCP-1 in gingival crevicular fluids
Time frame: Before surgery
monocyte chemotactic protein-1，MCP-1
Concentration of MCP-1 in gingival crevicular fluids
Time frame: 1 month after surgery
monocyte chemotactic protein-1，MCP-1
Concentration of MCP-1 in gingival crevicular fluids
Time frame: 3 months after surgery
oxidized low-density lipoprotein cholesterol, oxLDL
Concentration of oxLDL in gingival crevicular fluids and serum
Time frame: Before surgery
oxidized low-density lipoprotein cholesterol, oxLDL
Concentration of oxLDL in gingival crevicular fluids and serum
Time frame: 1 month after surgery
oxidized low-density lipoprotein cholesterol, oxLDL
Concentration of oxLDL in gingival crevicular fluids and serum
Time frame: 3 months after surgery
interleukin-8，IL-8
Concentration of IL-8 in gingival crevicular fluids
Time frame: Before surgery
interleukin-8，IL-8
Concentration of IL-8 in gingival crevicular fluids
Time frame: 1 month after surgery
interleukin-8，IL-8
Concentration of IL-8 in gingival crevicular fluids
Time frame: 3 months after surgery
triglycerides，TG
Concentration of TG in serum
Time frame: Before surgery
triglycerides，TG
Concentration of TG in serum
Time frame: 1 month after surgery
triglycerides，TG
Concentration of TG in serum
Time frame: 3 months after surgery
low-density lipoprotein cholesterol，LDL-C
Concentration of LDL-C in serum
Time frame: Before surgery
low-density lipoprotein cholesterol，LDL-C
Concentration of LDL-C in serum
Time frame: 1 month after surgery
low-density lipoprotein cholesterol，LDL-C
Concentration of LDL-C in serum
Time frame: 3 months after surgery
high-density lipoprotein cholesterol，HDL-C
Concentration of HDL-C in serum
Time frame: Before surgery
high-density lipoprotein cholesterol，HDL-C
Concentration of HDL-C in serum
Time frame: 1 month after surgery
high-density lipoprotein cholesterol，HDL-C
Concentration of HDL-C in serum
Time frame: 3 months after surgery
probing depth，PD
The distance (mm) from the bottom of the periodontal pocket to the gingival margin was measured with a periodontal probe (UNC-15, Hu-Friedy, Chicago, IL) parallel to the long axis of the tooth. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth.
Time frame: Before surgery
probing depth，PD
The distance (mm) from the bottom of the periodontal pocket to the gingival margin was measured with a periodontal probe (UNC-15, Hu-Friedy, Chicago, IL) parallel to the long axis of the tooth. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth.
Time frame: 1 month after surgery
probing depth，PD
The distance (mm) from the bottom of the periodontal pocket to the gingival margin was measured with a periodontal probe (UNC-15, Hu-Friedy, Chicago, IL) parallel to the long axis of the tooth. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth.
Time frame: 3 months after surgery
clinical attachment level，CAL
The periodontal probe measures the distance (mm) from the bottom of the gingival sulcus or the bottom of the periodontal pocket to the cementoenamel boundary. The mesial, median and distal 6 points of the labial (buccal) and lingual surfaces were recorded for each tooth.
Time frame: Before surgery
clinical attachment level，CAL
The periodontal probe measures the distance (mm) from the bottom of the gingival sulcus or the bottom of the periodontal pocket to the cementoenamel boundary. The mesial, median and distal 6 points of the labial (buccal) and lingual surfaces were recorded for each tooth.
Time frame: 1 month after surgery
clinical attachment level，CAL
The periodontal probe measures the distance (mm) from the bottom of the gingival sulcus or the bottom of the periodontal pocket to the cementoenamel boundary. The mesial, median and distal 6 points of the labial (buccal) and lingual surfaces were recorded for each tooth.
Time frame: 3 months after surgery
percentage of bleeding on probing，BOP%
Gently probe to the bottom of the bag or gingival sulcus, take out the probe and observe for 10-15 seconds to see if there is any bleeding. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. Calculate the percentage of bleeding sites.
Time frame: Before surgery
percentage of bleeding on probing，BOP%
Gently probe to the bottom of the bag or gingival sulcus, take out the probe and observe for 10-15 seconds to see if there is any bleeding. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. Calculate the percentage of bleeding sites.
Time frame: 1 month after surgery
percentage of bleeding on probing，BOP%
Gently probe to the bottom of the bag or gingival sulcus, take out the probe and observe for 10-15 seconds to see if there is any bleeding. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. Calculate the percentage of bleeding sites.
Time frame: 3 months after surgery
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