Cardiac Arrest and Ventilation Method

Seoul National University Hospital60 enrolled

Overview

Comparison of Manual Ventilation and Automatic Mechanical Ventilation during CPR, Pilot \& Feasibility Study (CAVE-I trial)

This is a preliminary randomized clinical trials comparing the effectiveness of the automatic mechanical ventilation method compared to manual ventilation methods commonly performed during advanced cardiac life support (ACLS) in emergency room for out-of-hospital cardiac arrest.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Out-Of-Hospital Cardiac Arrest Advanced Cardiac Life Support Ventilation

Interventions

Automatic Mechanical VentilationDEVICE

Ventilation settings: Mode: (S)Continuous Mandatory Ventilation Rate: 10 b/min. Tidal Volume: 500 ml (male), 450 ml (female) I:E=1:1 Positive end expiratory pressure (PEEP): 5 cmH2O Flow trigger: off Oxygen: 100% Alarms: Pressure 70 cmH20, Tidal volume 100 \~ 1,000 ml

Manual VentilationDEVICE

Ambu-bagging (It is recommended in the guidelines as a ventilation method.) Methods: 10 times per minutes by medical personnel

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Out-of-hospital cardiac arrest (OHCA) * Transferred by only EMS without prehospital return of spontaneous circulation (ROSC) * ACLS for at least 20 minutes in the emergency room * Arterial blood gas analysis at least once during ACLS Exclusion Criteria: * In-hospital cardiac arrest (IHCA) * Not transferred by Emergency Medical Service * ROSC gained before arriving at the ER * OHCA caused by trauma * ACLS is not performed for more than 20 minutes because the death is obvious * Not able to intubate the trachea

Locations (1)

Seoul Metropolitan Goverment-Seoul National University Boramae Medical Center

Seoul, Korea (the Republic Of), South Korea

Outcomes

Primary Outcomes

ROSC: return of spontaneous circulation

Rate of any ROSC after ACLS

Time frame: Within 20 minutes of ACLS

Secondary Outcomes

Arterial blood gas analysis (ABGA) parameters

PH (no unit), PO2 in mmHg, PCO2 in mmHg, HCO3 in mEq/L

Time frame: The first test was conducted within 5 minutes of ACLS, and the second test 10 minutes after the first test.

Ventilation parameters

Tidal volume (TV) and Minute volume (MV) during the entire ACLS

Time frame: During the entire ACLS time after randomization and endotracheal intubation

Data from ClinicalTrials.gov

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