This is a study about how a dietary supplement containing a whey protein affects hormones controlling hunger and satiety (leptin and ghrelin) in postmenopausal women with a body mass index between 28 and 35 kg/m2. Participants can expect to be in study for 4 weeks.
The purpose of this research study is to understand how a dietary supplement containing glycomacropeptide (GMP) affects blood sugar levels and hormones that regulate hunger and satiety. This study is being conducted to find new ways to help women lose weight and reduce their chance of getting diabetes.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
13
For each of the two baseline visits, women will consume a 300 calorie liquid breakfast meal tolerance test (MTT), eat a standard test lunch ad libitum with recording of food intake, and will then begin the low-dose GMP (25 g BID with meals) or high-dose GMP (25 g TID with meals) for 7 days. On day 7 of each GMP diet, women will come to the Clinical Research Unit (CRU) for a second breakfast MTT followed by lunch. All subjects will stop GMP products for 5-7 days (washout).
University of Wisconsin-Madison
Madison, Wisconsin, United States
Glucose homeostasis
Difference in glucose area under the curve after a soy versus a GMP liquid breakfast
Time frame: glucose levels 0, 15, 30, 45, 60, 90, 120 and 150 minutes postprandial
Ghrelin, a hormone regulating hunger and satiety
Difference in ghrelin area under the curve after a soy versus a GMP liquid breakfast
Time frame: ghrelin levels 0, 15, 30, 45, 60, 90, 120 and 150 minutes postprandial
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