The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.
High blood pressure (hypertension) is one of the most common medical disorders in pregnancy and affects 10% of all pregnancies in the United States, with possible short-term and long-term health complications including increased risk of stroke, and liver, kidney, and heart disease. Management of severe high blood pressure after delivery involves medications to lower blood pressure, strict discharge instructions and close follow- up after delivery. Both oral Nifedipine and oral Labetalol are considered safe agents for the treatment of postpartum high blood pressure, however few studies exist that directly compare the two. The investigators want to conduct this study because they want to compare the effects of oral Nifedipine or oral Labetalol on postpartum hypertension. In this study, subjects will get either oral Nifedipine or oral Labetalol. Subjects will not get both. No experimental drugs or devices will be used.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
500
Administration of oral nifedipine to control postpartum hypertension.
Administration of oral labetalol to control postpartum hypertension.
Loma Linda University Health
Loma Linda, California, United States
RECRUITINGComposite maternal morbidity
Requiring antihypertensive medication in the postpartum period, readmission for high blood pressure
Time frame: 0-6 weeks following delivery
Length of hospital stay of mothers
The length of hospital stay for mothers will be measured in hours from the time of admission to labor and delivery unit to the time of discharge from the post-partum unit.
Time frame: Number of hours between time of admission to time of discharge, up to 4 weeks from time of admission.
Total number of participants who have need for second antihypertensive agent
The need to use a second (alternative) antihypertensive medication.
Time frame: 0-6 weeks following delivery
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