The purpose of the study is to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH.
Postdural puncture headache (PDPH) is a severe and debilitating complication after regional anesthesia in the obstetric population; The gold standard treatment for PDPH is epidural blood patch, which is an invasive and risky procedure. The trans-nasal sphenopalatine ganglion (SPG) block and intravenous aminophylline are promising options for PDPH. So the investigators designed this randomized, double-blind study to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
75
bed rest, fluids, abdominal binder, oral paracetamol, and caffeine
conservative therapy plus Aminophylline (250mg of Aminophylline dissolved in 100ml normal saline for intravenous infusion over 30 minutes)
conservative therapy plus sphenopalatine ganglion block SPGB using hollow cotton swab and lidocaine 2%
faculty of medicine, Ain Shams University
Cairo, Egypt
the headache severity in the form of Visual Analogue score (VAS) at 12 hours after treatment.
0 - no pain to 10 - worst pain imaginable
Time frame: at 12 hours
Patient Global impression of change (PGIC) scale
Participant encircles number that match degree of change since the begining of care where 0- much better to 10- much worse and 5- no change.
Time frame: at 24 hours
Adverse effects
Recording of adverse effects arrhythmias, agitation, and nasal bleeding.
Time frame: at 24 hours
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