Carvedilol in HF With Preserved EF

Inclusion Criteria: * age ≥20 yrs * symptomatic HFpEF with LVEF≥50% * NT-proBNP ≥220 pg/ml (sinus rhythm) or ≥660 pg/ml(AF) (BNP ≥80 pg/ml (sinus rhythm) or ≥240 pg/ml(AF) ) * SBP≥140mmHg and/or DBP ≥90mmHg, or if taking anti-hypertensive medication, SBP ≥110mmHg. * LAVI≥29(sinus rhythm)/34ml/m2 (AF) or LVMI≥115(male)/95(female) g/m2 * meet one the following 1. Average E/e'≥ 9 2. Septal e' \< 7 cm/s 3. Lateral e' \<10 cm/s 4. TR velocity \> 2.8 m/s 5. PASP \> 35 mmHg 6. GLS \< 16% Exclusion Criteria: * systolic blood pressure \< 110 mmHg, or heart rate \< 60 beats/min * contra-indication to beta-blockers * creatinine\> 2.4mg/dL * amyloidosis, hypertrophic cardiomyopathy with obstruction, severe aortic or mitral valve disease, acute coronary syndrome, Cerebrovascular event within 6 months, PCI within 3 months before * AST/ALT \>3 x normal upper range