This study is a randomized, controlled, double-blinded, and parallel design study. A total 64 patients will be randomized to receive midazolam or normal saline during unruptured intracranial aneurysm clipping surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
64
Midazolam (0.03 mg/kg/30 min) will administered during UIA clipping through microscope.
Normal saline (0.03 mg/ml/30 min) will administered during UIA clipping through microscope.
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
RECRUITINGIntraoperative movement
Incidence
Time frame: During microscopic surgery
Motor evoked potential amplitude
amplitude
Time frame: immediately postoperative surgery
Motor evoked potential Latency
Latency
Time frame: immediately postoperative surgery
Duration of mechanical ventilation time
duration
Time frame: End of surgery to extubation time
Duration of ICU stay
duration of ICU stay, day
Time frame: From date of ICU admission until the date of first discharge from ICU, assessed up to 1 week
Satisfaction score for intraoperative environment
using 11-point score (0=worst dissatisfied, 10=very sattisfied)
Time frame: immediately postoperative surgery
Postoperative delirium
Incidence
Time frame: Postoperative 24 hour
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