Probiotic Supplementation During Pregnancy in Preeclampsia High-risk Groups

Inclusion Criteria: * PE high-risk population aged 18-50 years with gut microbiota dysbiosis * No severe cardiopulmonary diseases * No severe hepatic and renal insufficiency * No severe active infection * Pregnant women did not take antibiotics or antifungal drugs 30 days before fecal sample collection; No probiotic preparation was taken 2 weeks before sample collection; Never take drugs that may interfere with glucose and lipid metabolism * No diseases affecting intestinal microecology * No history of smoking and drinking * The researchers evaluated those pregnant women expected to deliver more than 20 weeks * Voluntarily participate in this clinical study and sign the informed consent form Exclusion Criteria: * With severe cardiopulmonary, hepatic and renal insufficiency * With uncontrolled active infections 2 weeks before enrollment * Subjects took antibiotics or antifungal drugs 30 days before sample collection; Take probiotics 2 weeks before sample collection; Have taken drugs that may interfere with glucose and lipid metabolism * with diseases affecting intestinal microecology * Smoking and drinking history * With acute gastrointestinal ulcer * Hemorrhagic constitution * Other discomfort assessed by the investigato