This study investigates the efficacy of landiolol versus placebo in patients with out-of-hospital cardiac arrest (OHCA) and refractory ventricular fibrillation (electrical storm).
The use of beta-blockers in OHCA patients with refractory VF could potentially reverse the unwanted beta-1-mediated effects of endogenous and exogenous epinephrine (proarrhythmic effect), which could in turn lead to a shorter time until return of spontaneous circulation (ROSC). This is a prospective, double-blind, randomized placebo-controlled pilot trial. The investigators consider this a pilot trial, as this is the first prospective trial evaluating the use of beta-blockade in cardiac arrest.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
32
patient receives landiolol in addition to standard-of-care
Placebo
Medical University of Vienna
Vienna, Austria
RECRUITINGTime to sustained return of spontaneous circulation (sROSC)
time from bolus infusion of landiolol OR placebo to sROSC
Time frame: Time of sROSC or termination of resuscitation efforts
rate of sustained ROSC
number of sustained ROSC per included patients
Time frame: Time of sROSC or termination of resuscitation efforts
number of shocks until sROSC
number of shocks until sROSC per included patients
Time frame: Time of sROSC or termination of resuscitation efforts
rate of temporary ROSC (any ROSC)
number of temporary ROSC per included patients
Time frame: Time of sROSC or termination of resuscitation efforts
survival to ICU admission
how many patients survived to ICU admission
Time frame: Time of ICU admission or termination of resuscitation efforts
mean/median length of stay in ICU
in days
Time frame: Time of transfer to open ward or death
mean/median length of hospital stay
in days
Time frame: Time of hospital discharge or death
survival until hospital admission
how many patients were admitted alive to the hospital
Time frame: Time of hospital admission or death
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survival until hospital discharge
how many patients survived to hospital discharge
Time frame: Time of hospital discharge or death
favorable neurologic outcome at hospital discharge, day 28, month 3, 6, 12 (CPC and mRS)
measured by CPC and mRS
Time frame: at hospital discharge, day 28, month 3, 6, 12
survival at hospital discharge, day 28, month 3, 6, 12
how many patients survived to day 28, month 3, 6, 12
Time frame: at hospital discharge, day 28, month 3, 6, 12