Enhancing the Effectiveness of Cognitive Behavioral Therapy Using Non-invasive Brain Stimulation

University of Manitoba30 enrolled

Overview

The purpose of the proposed study is to examine if a repeated treatment of High Definition Transcranial Direct Current Stimulation (HD-tDCS) can increase the functional connectivity between the left ventrolateral prefrontal cortex and posterior cingulate, which may further enhance the effects of cognitive behavioral therapy with mindfulness classes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Depression Anxiety Stress Disorders, Post-Traumatic

Interventions

MxN-9 HD-tES Stimulator (Soterix Inc.)DEVICE

Patients will be stimulated with high definition transcranial direct current stimulation (HD-tDCS) for 5 weeks (every weekdays; one session per day). In each session, a constant current at 2mA will be passed on the target brain areas for 20 minutes.

Sham StimulationDEVICE

The same stimulation protocol will be used as in Active stimulation except that a sham mode will be selected in the stimulator machine.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * all patients who have agreed to participate in virtual mental health treatment at health care sites throughout Manitoba. Eligible participants will be those enrolled in a range of mental health programs, including CBT, DBT, virtual hospital wards, and group-based treatment (e.g., CBTm, Managing Difficult Emotions, etc). The target population will also include providers and decision makers offering virtual mental health programs. Individuals must meet the following criteria to be eligible to participate in the study: 1) must be a patient/client enrolled in a virtual mental health program OR a provider/decision maker offering a virtual mental health program, and 2) located within Manitoba Exclusion Criteria: * contraindication for MRI (e.g., metallic implants and claustrophobia)

Locations (1)

University of Manitoba

Winnipeg, Manitoba, Canada

RECRUITING

Outcomes

Primary Outcomes

Functional Connectivity

Functional Connectivity between the targeted brain regions measured by resting state fMRI (level of synchronous fMRI signal, standardized)

Time frame: Change from Baseline Functional Connectivity after 5 month HD-tDCS/CBTm treatment

Central Contacts

Eun Hyung Choi

CONTACT

204-787-4897 eun.choi@umanitoba.ca

Data from ClinicalTrials.gov

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