Effect of Individualized Precise TMS on Emotional Blunting in Depression and Its Brain Imaging Mechanism

Inclusion Criteria: * (1) Outpatients of all genders, aged ≥18 years and ≤65 years, right-handed, admitted to the psychosomatic Department of Xijing Hospital; (2) In accordance with the diagnostic criteria for the depressive disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)). (3) Montgomery-Asberg Depression Rating Scale (MADRS): total MADRS score ≥12; (4) The total score of the Oxford Depression Questionnaire (ODQ) at baseline was ≥50, and the answer to the standardized screening question of emotional blunting was "yes"; (5) Received at least 6 weeks of monotherapy with an SSRI or SNRI prior to enrollment; (6) Subjects who can understand and are willing to strictly follow the clinical trial protocol to complete this study and sign informed consent. Exclusion Criteria: * (1) Have a history of substance abuse within 6 months before the start of the study; (2) Patients with bipolar disorder and depression caused by other mental diseases (such as psychoactive substances and non-dependent substances); (3) Have a history of somatic severe diseases or diseases that may affect the central nervous system (such as tumors, syphilis, etc.); (4) Have neurological diseases or risk of seizures, such as previous brain diseases, head trauma, alcoholism, EEG abnormalities, MRI evidence of abnormal brain structure, or family history of epilepsy; (5) There are contraindications to MRI scanning or transcranial magnetic stimulation treatment, such as metal or electronic instruments (intracranial metal foreign bodies, cochlear implants, cardiac pacemakers, stents, and other metal foreign bodies); (6) Have obvious suicide risk, or have actual suicide behavior within 6 months before the start of the study; (7) Pregnant, breastfeeding, or planning pregnancy during the trial; (8) Other conditions that are not suitable for the study object in the researcher's judgment.