The Relation Between MiR-125b-5p and Staging of Endometriosis

Tanta University89 enrolled

Overview

78 endometriosis patients presented with infertility were clinically examined and the diagnosis was assured by US imaging. The study also included 11 control fertile women free of gynecological problems as a control for lab tests. Patients and controls gave blood samples for lab investigations. All patients underwent diagnostic abdominal laparoscopy under general anesthesia for disease staging. Quantitative determination of expression levels of genes of microRNA-125b-5p and 203a was conducted using qRT-PCR.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Endometriosis

Interventions

laparoscopic examinationPROCEDURE

laparoscopic examination for staging of endometriosis

Blood samplingDIAGNOSTIC_TEST

Blood sample to detect endometriosis

Eligibility

Sex: FEMALEMin age: 22 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who presented clinical pictures suggestive of EM disease Exclusion Criteria: * Patients with previous pelvic or abdominal surgery that may hinder the laparoscopic examination, * patients who were suspicious of having malignancy elsewhere in the body region, * pregnant women, * patients who had diabetes mellitus, * body mass index (BMI) of \>30 kg/m2, coagulopathies, and autoimmune disorders.

Locations (1)

Tanta university

Tanta, El-Gharbyia, Egypt

Outcomes

Primary Outcomes

Validity of Plasma expression level

the diagnostic validity of estimation of plasma expression levels of MiR-125b-5p and 203a for diagnosis and staging of endometriosis.

Time frame: two weeks

Data from ClinicalTrials.gov

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