This study is a randomized, controlled trial. A total of 72 patients will be randomized to receive remimazolam anesthesia or balanced anesthesia (propofol + desflurane) during extracranial-intracranial bypass surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
72
Anesthesia induction: remimazolam 6-12 mg/kg/h Anesthesia maintenance: remimazolam 1-2 mg/kg/h
Anesthesia induction: propofol 1.5-2 mg/kg Anesthesia maintenance: Desflurane 6-8 vol%
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
RECRUITINGIntraoperative hypotension
Target Systolic Blood Pressure \< 80%
Time frame: During surgery
Inotropic requirements
Dose of inotropics administered during surgery
Time frame: During surgery
Incidence of bradycardia
heart rate \< 40 /min
Time frame: During surgery
Incidence of tachycardia
heart rate \> 100 /min
Time frame: During surgery
Maximum systolic blood pressure
Maximal systolic blood pressure during surgery (mmHg)
Time frame: During surgery
Minimum systolic blood pressure
Minimal systolic blood pressure during surgery (mmHg)
Time frame: During surgery
Brain relaxation score
1=perfectly relaxed, 2=satisfactorily relaxed, 3=firm brain, 4=bulging brain
Time frame: Immediately after dura opening
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