Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants, and how they change in diseased states such as preterm birth or retinopathy of prematurity.
Study Type
OBSERVATIONAL
Enrollment
16
OCT systems are in vivo optical imaging technology that allows non-contact imaging of early-stage ocular pathology. They create real-time, non-invasive images of ocular microstructure and have become standard-of-care instruments in ophthalmic imaging in clinics and operating rooms. In contrast to the visible light used in clinical eye examinations, because infrared light is not visible, the participant is not disturbed by the light. OCT imaging allows the capture of hundreds of B-scan (cross-sectional) images in seconds. These B-scans are analyzed for depth-resolved information and can also be stacked to create a volume and the stack may be summed up to create a retinal image. OCT angiography (OCTA) is an extension of the OCT systems, by taking images at the same location over time to extract retinal vascular flow information. It has been utilized to assess the ocular blood flow in many adult and pediatric patients.
Duke University
Durham, North Carolina, United States
RECRUITINGUniversity of Pennsylvania
Philadelphia, Pennsylvania, United States
NOT_YET_RECRUITINGChange in vascular density of intermediate and deep vascular plexus at the fovea and perifovea
Measured by retinal OCTA imaging.
Time frame: During hospitalization (at approximately 32-44 weeks post menstrual age, PMA)
Change in vascular density of superficial vascular plexus at the fovea and perifovea
Measured by retinal OCTA imaging.
Time frame: During hospitalization (at approximately 32-44 weeks post menstrual age, PMA)
Change in avascular zone size of superficial, intermediate and deep vascular plexus
Measured by retinal OCTA imaging.
Time frame: During hospitalization (at approximately 32-44 weeks post menstrual age, PMA)
Change in network length of intermediate and deep vascular plexus
Vascular density of superficial vascular plexus at the fovea and perifovea; Avascular zone size of superficial, intermediate and deep vascular plexus; Network morphology of intermediate and deep vascular plexus; Network length of intermediate and deep vascular plexus.
Time frame: During hospitalization (at approximately 32-44 weeks post menstrual age, PMA)
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