Impact of Periodontal Bacteria on the Effectiveness of Periodontal Therapy

University of Catania88 enrolled

Overview

In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the protocols for the management of periodontitis, the aim of this study was to evaluate, at 6 months follow-up, the post-treatment clinical parameters and immunological and gingival microbial profiles in patients with periodontitis, treated by either SRP in addition to full mouth periodontal debridement.

This trial was conducted in accordance with the World Medical Association's Declaration of Helsinki of 1975, and reviewed in 2008. Patients were enrolled from January 2020 to December 2022. The local ethical committee of approved the study protocol (125/PO) and each patient was carefully informed about the possible inherent risks of the study and provided their informed written consent 88 patients, aged 27 to 65 (mean age 57) were assessed for eligibility. In all subjects, subgingival plaque will acquired from 4 separate proximal periodontal sites.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Periodontitis

Interventions

Scaling and root planingPROCEDURE

Full mouth or quadrant SRP

Eligibility

Sex: ALLMin age: 25 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. good condition of general health, 2. a minimum of 2 teeth for each quadrant with a Pocket Depth (PD) ranging from 4-6 mm, 3. no involvement of the furcation, 4. a minimum of a six teeth per quadrant, respectively. Exclusion Criteria: 1. periodontal therapy during the last 12 months, 2. assumption of antibiotics during the last 6 months, 3. pregnancy, 4. any systemic condition which might affect the effects of the study treatment, 5. previous or current radiation or immunosuppressive therapies, 6. use of mouthwash containing antimicrobials during the previous 3 months, 7. no use of hormonal contraceptives, 8. medication by anti-inflammatory and immunosuppressive drugs, 9. previous history of hard-drinking, 10. smoking, 11. class II and III tooth mobility.

Locations (1)

University of Catania

Catania, CT, Italy

Outcomes

Primary Outcomes

Probing depth changes

Measurment of Probing Depth changes in millimeters

Time frame: 6 months

Data from ClinicalTrials.gov

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