Brain Network Characteristics in Patients With Disorders of Consciousness

Xijing Hospital40 enrolled

Overview

Simultaneous measurement of the three modalities, functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and electroencephalography (EEG) was proven to be feasible and advantageous in evaluating brain structural and functional (via fMRI), metabolic (via PET) and electrophysiological (via EEG) signatures simultaneously under the same conditions. Investigators use trimodal PET-fMRI-EEG imaging to explore the characteristics of brain network damage in patients with disorders of consciousness(DOC), assess the trajectory of consciousness recovery in a prospective observational cohort study.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Disorders of Consciousness

Interventions

PET-fMRI-EEGOTHER

Participants perform PET, fMRI, and EEG simultaneously using a MRI compatible EEG cap

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Coma, VS/UWS, MCS and EMCS according to diagnostic criteria 2. Age ≥18 years 3. Written informed consent obtained Exclusion Criteria: 1. Patients with contraindications to PET, MRI, EEG examinations or inability to complete PET-fMRI-EEG examinations (presence of ferromagnetic metal implants or hyperthermia) 2. Hyperglycemia that is difficult to correct 3. Patients with long-term use of corticosteroids 4. Patients with coexisting severe systemic disease and limited life expectancy

Locations (1)

Xijing hospital

Xi'an, Shaanxi, China

RECRUITING

Outcomes

Primary Outcomes

CRS-R total score

The coma recovery scale-revised(CRS-R) total score is used to measure level of consciousness of disorder in enrolled patients. CRS-R consists of six subscales addressing auditory, visual, motor, verbal, communication, and arousal functions.The lowest item on each subscale represents reflexive activity and the highest item represents cognitively mediated behavior. Maximum scores of each subscale are summed to obtain the total score (from 0 to 23).The score for each subscale is based on the presence or absence of a specific behavioral response to a sensory stimulus (higher scores are better).

Time frame: Patients in coma after 3 weeks enrolled

GOSE score

Glasgow Outcome Scale-Extended(GOSE) score is used to measure the functional limitations of participants. GOSE is a 1-8 point scale (1 = Death, 2 = Vegetative State, 3 = Lower Severe Disability, 4 = Upper Severe Disability, 5 = Lower Moderate Disability, 6 = Upper Moderate Disability, 7 = Lower Good Recovery, and 8 = Upper Good Recovery). Patients with higher scores are more independent.

Time frame: Patients are followed up for 6 months after enrolled

Central Contacts

Rong Chen

CONTACT

18292575563 cmuchenrong@126.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.