The purpose of this study is to describe the progression of tissular and functional myocardial abnormalities in patients with Duchenne muscular dystrophy using cardiac magnetic resonance imaging and blood biomarkers assays.
This study is to describe the progression of tissular (late gadolinium enhancement, T1, T2, ECV assessments) and functional (segmental and global contractility, strain) myocardial abnormalities in patients with Duchenne muscular dystrophy using cardiac magnetic resonance imaging and blood biomarkers assays (troponin I, NTproBNP). Comparison between baseline and 2-years assessments will be conducted.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
two cardiac MRIs with Gadolinum injection at 2-year intervals
blood samples for the determination of blood biomarkers of heart failure (BNP, NTproBNP) and for the constitution of a biological collection
Necker Hospital
Paris, France
Late gadolinium enhancement burden on cardiac MRI
Time frame: 2 years
Global T1 on cardiac MRI
Time frame: 2 years
Global T2 on cardiac MRI
Time frame: 2 years
Global extracellular volume on cardiac MRI
Time frame: 2 years
Left ventricular ejection fraction on cardiac MRI
Time frame: 2 years
Left ventricular systolic circumferentiel strain ejection fraction on cardiac MRI
Time frame: 2 years
Left ventricular systolic radial strain ejection fraction on cardiac MRI
Time frame: 2 years
Left ventricular systolic longitudinal strain on cardiac MRI
Time frame: 2 years
NTproBNP assay in the blood
Time frame: 2 years
Troponin I assay in the blood
Time frame: 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.