The study observes real world patients with primary hypercholesterolemia who receive a fixed dose combination therapy with atorvastatin and ezetimibe for 24 weeks; collects and analyzes data related to efficacy and safety of the therapy; and evaluates efficacy and safety of the fixed dose combination therapy with atorvastatin and ezetimibe.
The prevalence of hypercholesterolemia, an atherosclerotic dyslipidemia which is the major cause of coronary artery diseases has risen. According to numerous studies, LDL-C is the key cause of atherosclerosis and it has been reported that treating patients to lower the LDL-C level will reduce the incidence of cardiovascular diseases. Currently, patients are classified into risk groups to receive a recommended therapy based on the defined criteria in Korea and Statin is the primary therapeutic agent recommended. However, there have been concerns that an increased dose of statins may result in hepatoxicity and reports that a combination therapy with ezetimibe without an additional dose of statins has clinical benefits. Ezetimibe is a drug that inhibits cholesterol absorption in the small intestine and reduces the LDL-C level. The therapeutic guideline, first of all, recommends combination therapy with ezetimibe among other drugs whose clinical benefits have been confirmed in cases where the target LDL-C level is not met with statins. The study observes real world patients with primary hypercholesterolemia who receive a fixed dose combination therapy with atorvastatin and ezetimibe for 24 weeks; collects and analyzes data related to efficacy and safety of the therapy; and evaluates efficacy and safety of the fixed dose combination therapy with atorvastatin and ezetimibe. During this study period, the scope of data to be collected is as follows: * Demographic data * Indication diagnosis and characteristics * Cardiovascular risk * Medical history * Statin medication * Preceding/Concomitant drug * Administration of fixed dose combination therapy with atorvastatin and ezetimibe * Collecting efficacy endpoints: Lipid profile(LDL-C, TC, TG, HDL-C, non-HDL-C) * Collecting safety endpoints: ADR, SAE, SADR, HbA1C, FPG, AST, ALT, CPK
Study Type
OBSERVATIONAL
Enrollment
1,839
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Rate of reaching the target LDL-C level
Rate of reaching the target LDL-C level at Week 24
Time frame: Week 24
Rate of reaching the target LDL-C level
Rate of reaching the target LDL-C level at Week 12
Time frame: Week 12
Rate of change compared to the baseline when it comes to the level of TC, TG, LDL-C, HDL-C and non-HDL-C
Rate of change at Week 12 and Week 24 compared to the baseline when it comes to the level of TC, TG, LDL-C, HDL-C and non-HDL-C
Time frame: Week 12 and Week 24
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