Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy

Mahidol University404 enrolled

Overview

This is a prospective randomized placebo-controlled trial to evaluate the efficacy of peppermint oil spraying into the colonic lumen through the scope channel during screening colonoscopy. The primary outcome is to compare the colonic peristalsis between peppermint oil and placebo. The secondary outcomes compare the procedural time, polyp detection rate, adenoma detection rate, and adverse events.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

QUADRUPLE

Enrollment

404

Conditions

Colonic Polyp

Interventions

Intraluminal peppermint oilDRUG

Intraluminal flushing of peppermint oil solution through the scope channel during the scope withdrawal

PlaceboDRUG

Intraluminal flushing of placebo solution through the scope during scope withdrawal

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Participants with age \> 18 years who attended for colorectal cancer screening colonoscopy. Exclusion Criteria: * Participants who had been colectomy * Participants who diagnosed of inflammatory bowel disease or polyposis syndrome. * Participants who had been took anti-spasmosic drugs prior to colonoscopy within 24 hours (Anticholibergic/Antimuscarinic : Hyoscine(Buscopan®), Dicyclomine(Berclomine®) or Smooth muscle relaxant : Mebeverine(Duspatin®,Colofac®), Pinaverium bromide(Dicetel®), Alverine(Meteospasmyl®), Peppermint oil(Colpermin®)) * Participants with Prothrombin time \> 3 second ULN, INR \> 1.5 or Platelet \< 50,000. * Pregnancy or breast feeding * Participants who cannot consent. * Participants who had history of peppermint oil allergy.

Locations (1)

Faculty of internal medicine siriraj hospital, Mahidol university

Bangkok Noi, Bangkok, Thailand