The purpose of this study is to explore the relationship between periodontal disease and coronary artery disease through changes in the gut microbiome. In addition, the investigators aim to find possible periodontal pathogens that have association with cardiovascular disease.
The previous studies have reported the associations among cardiovascular disease, periodontitis, and gut microbiome dysbiosis. However, there is a lack of evidences about the axis of association from oral-gut-cardiovascular disease. The investigators hypothesized that periodontal disease might induce dysbiosis of gut microbiome and dysbiosis might have a role in cardiovascular disease (as called "oro-gut-vascular axis"). The investigators aim to prove this hypothesis through this case-control, cross-sectional study.
Study Type
OBSERVATIONAL
Enrollment
450
Yonsei University Health System, Severance Hospital
Seoul, South Korea
The association between periodontal disease and cardiovascular disease
The association between periodontal disease and cardiovascular disease by chi-square test The difference of relative abundance in gut microbiome by PERMANOVA test Safety Issue: No
Time frame: within 3 years after enrollment (until the completion of dataset)
The associations among periodontitis, gut microbiome and biomarkers
The association between periodontal disease and biomarkers by independent t-test
Time frame: within 3 years after enrollment (until the completion of dataset)
The associations between periodontitis and cognitive function
The associtation between periodontal disease and cognitive function by chi-square test
Time frame: within 3 years after enrollment (until the completion of dataset)
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