The purpose of this study is to evaluate the measures of brain function, both neurophysiological (event-related potentials (ERPs) and functional (cognitive assessments), in response to sleep deprivation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
48
Participants will be randomized into either the sleep deprivation group or the control group, who will sleep regularly.
On Day 2 morning, after the sleep deprivation or sleeping, participants will be randomized into receiving caffeinated or de-caffeinated coffee, which they will be blinded to.
De-caffeinated coffee
HealthTech Connex Centre for Neurology Studies
Surrey, British Columbia, Canada
Change in NeuroCatch® Platform 2 (NCP2), event-related potentials (ERPs) Amplitudes
N100, P300 and N400 amplitude values
Time frame: 2 days
Change in NeuroCatch® Platform 2 (NCP2), event-related potentials (ERPs) Latencies
N100, P300 and N400 latency values
Time frame: 2 days
Change in Cogstate cognitive assessment Accuracy scores from Baseline, Baseline 2 and Study Visit 3 (post-intervention)
accuracy (% of correct responses) scores
Time frame: 2 days
Change in Cogstate cognitive assessment Reaction time scores from Baseline, Baseline 2 and Study Visit 3 (post-intervention)
reaction time (ms) scores
Time frame: 2 days
Change in NeuroCatch® Platform 2 (NCP2), event-related potentials (ERPs) pre and post caffeine intervention
N100, P300 and N400 amplitude and latency values
Time frame: 1 day
Change in Cogstate cognitive assessment measures (Detection Test, Identification Test, One Card Learning, and One Back Task) from Baseline, Baseline 2 and Study Visit 3 (post-intervention)
Cogstate accuracy (% of correct responses) and reaction time (ms) scores
Time frame: 1 day
Safety Measures
Frequency, severity and type of AEs, ADEs, and DDs
Time frame: 2 days
Demographics
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 1 day
Medical History
Time frame: 1 day