The aim of the study is to make an accurate assessment of immune cells obtained from nasal mucosa and peripherial blood of MIS-C patients during the disease and the period of health.
The study will consist of two parts. Initially, it will be of a cross-cutting comparative nature, when a group of healthy patients (control group) and a group of patients diagnosed with MIS-C/PIMS syndrome are compared with each other, based on nasal curettage swabs and peripheral blood, before the inclusion of systemic anti-inflammatory treatment (study group). In addition, an observation of the research group will be carried out, during which swabs and peripheral blood will be taken at two more control points.
Study Type
OBSERVATIONAL
Enrollment
20
Pediatric teaching clinical hospital, Warsaw Medical University
Warsaw, Masovian Voivodeship, Poland
RECRUITINGChange in leukocyte subpopulations in nasal mucosa and peripherial blood during MIS-C and convalescence.
The cellular subpopulations will be characterized and clustered using prepared immunomarker array.
Time frame: Three clinical timepoints: (i) baseline (preferably before immunomodulatory treatment), (ii) convalescence, after major symptoms resolution (1 week +/-2 days after treatment introduction), (iii) outpatient control visit (6 weeks after hospital discharge)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.