Phase Ⅰa Clinical Study of Hawthorn Red Pigment Combined With Standard Analgesic for Refractory Cancer Pain

Inclusion Criteria: 1. Patients aged 18-80 years with malignant tumor confirmed by pathology; 2. Refractory cancer pain, that is, patients coexist: 1) digital score of persistent pain ≥ 4 points and / or number of eruptive pain ≥ 3 times / day; 2) Following the relevant guidelines for cancer pain treatment, the pain relief of patients treated with opioids alone and / or combined with adjuvant analgesics for 1-2 weeks is still unsatisfactory and / or intolerable adverse reactions occur; 3. Patients who need chemotherapy, long-term hormone, targeted therapy or bisphosphate therapy had stable anti-tumor therapy before randomization; 4. Patients or their nursing staff can fill in the survey form; 5. Correctly understand and cooperate with medical staff in medication guidance; 6. No mental illness; 7. ECOG-ps ≤ 3 points; 8) Did not participate in the drug test (including the test drug) within one month before the test; 8. The subjects volunteered and signed the informed consent. Exclusion Criteria: 1. patient is diagnosed with non cancerous pain or pain of unknown cause; 2. Postoperative pain of patients; 3. Patients with paralytic intestinal obstruction; 4. Patients with metastatic brain cancer; 5. Patients with opioid allergy / addiction; 6. Abnormal laboratory results with obvious clinical significance, such as creatinine ≥ upper limit of normal value, ALT or AST ≥ 2.5 times of upper limit of normal value (liver metastasis patients or primary liver cancer ≥ 5 times of upper limit of normal value), or child C level of liver function; 7. Patients who cannot take drugs orally; 8. Uncontrollable nausea and vomiting; 9. Patients with a history of gastritis and gastric ulcer; 10. Patients who need to use nonsteroidal drugs and steroid hormone drugs for analgesia; 11. Diabetes patients who can't control blood sugar stably; 12. Pregnant and lactating women; Subjects with pregnancy plans within 1 month after the trial (including male subjects); 13. Alcoholics; 14. Patients with cognitive impairment; 15. Patients with severe depression; 16. Diseases and conditions that other researchers consider not to be included.