Efficacy and Safety of Daratumumab in Combination With Bortezomib, Thalidomide, and Dexamethasone Regimens in Newly Diagnosed Multiple Myeloma

Inclusion Criteria: 1. newly diagnosed multiple myeloma; 2. age over 18 years, male or female; 3. glomerular filtration rate (eGFR) \< 40 mL/min 4. Patients must have the ability to understand and voluntarily sign the informed consent form, which must be signed before any trial process; 5. patients who completed at least one course of treatment were included in the safety observation; 6. Patients who completed at least 2 courses of treatment were included in the efficacy observation; Exclusion Criteria: 1. acute and chronic renal insufficiency not caused by myeloma; 2. are receiving any other investigational drug or investigational medical device; 3. Patients with other cancers confirmed before MM diagnosis, except cervical carcinoma in situ or scaly cell carcinoma of the skin and basal cell carcinoma that are considered cured for more than 3 years before enrollment; 4. patients who do not complete a course of DVTd treatment for any reason, unless permanent discontinuation or death due to the drug;