Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers

Insel Gruppe AG, University Hospital Bern70 enrolled

Overview

The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue. Up to now, to the best of the investigator's knowledge, there is no study reporting the use of vocal biomarkers to predict these three non-motor symptoms in people with MS.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple Sclerosis

Interventions

Voice analysisOTHER

Voice analysis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Relapsing MS * Age over 18 * EDSS \< 4.0 * Capability of written informed consent Exclusion Criteria: * Not fluent in german language * Relapse or Steroids per os/intra venous \< 4 weeks prior to examination * KM enhancing lesion in MRI \< 4 weeks prior to examination * Other previous disease affecting the speech * Pregnant patients * Mental disability and not able to understand the protocol and study tasks in german languagePatients with greater physical and cognitive disability or history of major depressive disorder and suicide attempt/suicidal thoughts * Patients with sleep disorders and comorbidities associated with extreme fatigue (e.g., fibromyalgia)

Locations (1)

Inselspital University Hospital Bern

Bern, Switzerland

Outcomes

Primary Outcomes

Identification of a voice signature that separates between pwMS with and without fatigue

Time frame: One year

Secondary Outcomes

Identification of a voice signature that separates between pwMS with and without cognitive impairment

Time frame: One year

Identification of a voice signature that separates between pwMS with and without depression

Time frame: One year

Data from ClinicalTrials.gov

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