EEG Diagnostic for Repetitive Sub-concussive Head Impacts

Mayo Clinic42 enrolled

Overview

The purpose of this study is to develop a diagnostic algorithm to help with the detection, diagnosis, and monitoring of sub-concussive head impacts.

This prospective study will investigate the potential effects of soccer ball heading on EEG and oculomotor measurements.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Concussion

Eligibility

Sex: ALLMin age: 18 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 - 38 years of age. * Have at least 1 year of experience playing soccer. * Played soccer within the prior year. * Head soccer ball during practice and/or games. Exclusion Criteria: * Subjects with a history of TBI during the prior 12 months. * History of moderate or severe Traumatic Brain Injury (TBI). * History of seizures. * Medical or psychiatric history the precludes participation. * Currently receiving treatment in another research study. * History of a condition with vestibular, ocular, or vision dysfunction.

Locations (1)

Mayo Clinic in Arizona

Phoenix, Arizona, United States

Outcomes

Primary Outcomes

Change in EEG Signals

Sensitivity of a machine-learning based algorithm containing changes in EEG signals and functional connectivity for distinguishing research participants who headed a soccer ball from research participants who kicked the ball. A leave-one-out cross validation approach will be used.

Time frame: Baseline, 45 minutes post-heading, 24 hours post-heading

Secondary Outcomes

Change in Eye Tracking Parameters

Sensitivity of a model containing changes in eye tracking measurements for distinguishing research participants who headed a soccer ball from research participants who kicked the ball.

Time frame: Baseline, 45 minutes post-heading, 24 hours post-heading

Change in King-Devick Testing Scores

Sensitivity of a model containing changes in King-Devick test scores for distinguishing research participants who headed a soccer ball from research participants who kicked the ball.

Time frame: Baseline, 45 minutes post-heading, 24 hours post-heading

Data from ClinicalTrials.gov

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