Pain will bring early and long-term adverse reactions to infants. The investigators need to pay attention to whether there is pain in infants after surgery. Since infants cannot self-report pain,The investigators need to use appropriate pain assessment scale to evaluate the pain of these infants, so as to understand the status of postoperative pain in children. The result of pain score not only enables investigators to understand the pain status of children, but also helps investigators to give corresponding intervention and treatment according to the pain degree of children. Postoperative pain management is one of the core contents of ERAS. Effective pain management is beneficial to the early postoperative recovery of infants and reduces the adverse reactions caused by pain. Sveral studies have confirmed that the combination of acetaminophen and opioids could reduce the use of opioids after surgery. But even if opioid use is reduced, it still causes many side effects for children. This study evaluated the safety and efficacy of acetaminophen alone for postoperative analgesia in infants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
220
When the infants woke up after surgery and were transported back to the ward, they were randomly divided into two groups immediately. The intervention group was given oral acetaminophen, once every 6 hours, for a total of 4 times.
When the infants woke up after surgery and were transported back to the ward, they were randomly divided into two groups immediately. The control group was given sterilized water, once every 6 hours, for a total of 4 times.
Children's Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Using CRIES scale to assess the pain level at 12 hours after postoperative awakening
The pain score was evaluated 12 hours after Children wake up
Time frame: 12 hours after postoperative awakening
liver function
alanine aminotransferase, aspartate aminotransferase
Time frame: 48 hours after surgery
renal function
urea and creatinine values
Time frame: 48 hours after surgery
LOS
Length of stay after surgery
Time frame: 30 days after surgery
Using CRIES scale to assess the pain level at 1 hour after postoperative awakening
The pain score was evaluated 1 hour after Children wake up
Time frame: 1 hour after postoperative awakening
Using CRIES scale to assess the pain level at 6 hours after postoperative awakening
The pain score was evaluated 6 hours after Children wake up
Time frame: 6 hours after postoperative awakening
Using CRIES scale to assess the pain level at 18 hours after postoperative awakening
The pain score was evaluated 18 hours after Children wake up
Time frame: 18 hours after postoperative awakening
Using CRIES scale to assess the pain level at 24 hours after postoperative awakening
The pain score was evaluated 24 hours after Children wake up
Time frame: 24 hours after postoperative awakening
Using CRIES scale to assess the pain level at 36 hours after postoperative awakening
The pain score was evaluated 36 hours after Children wake up
Time frame: 36 hours after postoperative awakening
Using CRIES scale to assess the pain level at 48 hours after postoperative awakening
The pain score was evaluated 48 hours after Children wake up
Time frame: 48 hours after postoperative awakening
Using FLACC scale to assess the pain level at 1 hour after postoperative awakening
The pain score was evaluated 1 hour after Children wake up
Time frame: 1 hour after postoperative awakening
Using FLACC scale to assess the pain level at 6 hours after postoperative awakening
The pain score was evaluated 6 hours after Children wake up
Time frame: 6 hours after postoperative awakening
Using FLACC scale to assess the pain level at 12 hours after postoperative awakening
The pain score was evaluated 12 hours after Children wake up
Time frame: 12 hours after postoperative awakening
Using FLACC scale to assess the pain level at 18 hours after postoperative awakening
The pain score was evaluated 18 hours after Children wake up
Time frame: 18 hours after postoperative awakening
Using FLACC scale to assess the pain level at 24 hours after postoperative awakening
The pain score was evaluated 24 hours after Children wake up
Time frame: 24 hours after postoperative awakening
Using FLACC scale to assess the pain level at 36 hours after postoperative awakening
The pain score was evaluated 36 hours after Children wake up
Time frame: 36 hours after postoperative awakening
Using FLACC scale to assess the pain level at 48 hours after postoperative awakening
The pain score was evaluated 48 hours after Children wake up
Time frame: 48 hours after postoperative awakening
Using CHIPPS scale to assess the pain level at 1 hour after postoperative awakening
The pain score was evaluated 1 hour after Children wake up
Time frame: 1 hour after postoperative awakening
Using CHIPPS scale to assess the pain level at 6 hours after postoperative awakening
The pain score was evaluated 6 hours after Children wake up
Time frame: 6 hours after postoperative awakening
Using CHIPPS scale to assess the pain level at 12 hours after postoperative awakening
The pain score was evaluated 12 hours after Children wake up
Time frame: 12 hours after postoperative awakening
Using CHIPPS scale to assess the pain level at 18 hours after postoperative awakening
The pain score was evaluated 18 hours after Children wake up
Time frame: 18 hours after postoperative awakening
Using CHIPPS scale to assess the pain level at 24 hours after postoperative awakening
The pain score was evaluated 24 hours after Children wake up
Time frame: 24 hours after postoperative awakening
Using CHIPPS scale to assess the pain level at 36 hours after postoperative awakening
The pain score was evaluated 36 hours after Children wake up
Time frame: 36 hours after postoperative awakening
Using CHIPPS scale to assess the pain level at 48 hours after postoperative awakening
The pain score was evaluated 48 hours after Children wake up
Time frame: 48 hours after postoperative awakening
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