Impact of High Dietary Fiber on Microbiome and Vaccine Responses

Inclusion Criteria: 1. MD Anderson employees with existing MRNs 2. Body Mass Index (BMI) 18.5-40 kg/m2 3. Age 18 or older 4. Intends to receive the seasonal influenza vaccine at MD Anderson through Employee Health (starting Fall of 2022) 5. Willing to adhere to the provided dietary interventions 6. Willing to provide blood and stool specimens, complete diet questionnaires and logs, and pick up food on-site within the study schedule 7. English-speaking 8. Has easy access to a scale at home, work, or in their community Exclusion Criteria: 1. Contraindication to the recommended annual influenza vaccine 2. Medical contraindications to the intervention diet 3. Major dietary restrictions (including vegetarian or vegan diets) or food allergies 4. Unable or unwilling to undergo study procedures 5. Has diabetes mellitus requiring medical treatment 6. Has inflammatory bowel disease 7. Has a history of bariatric surgery 8. Has a history of major gastrointestinal surgery (not including appendectomy or cholecystectomy) 9. Antibiotic use within 30 days of study initiation or planned antibiotic treatment during study course 10. Habitual consumption of a high fiber diet 11. Use of a supplement containing fiber/prebiotics/probiotics within 30 days of study initiation 12. Women who are pregnant, planning to become pregnant, or who are lactating may not be included in this study