The Effect of Perioperative DEXamethasone on Postoperative Complications After PANcreaticoduodenectomy

Inclusion Criteria: 1. Adult patients ≥18 years of age; 2. An indication for elective PD surgery; 3. Patients understand the nature of this trial and are willing to comply; 4. Patients are able to provide written informed consent; Exclusion Criteria: 1. Current or recent (within preceding 1 month) systemic use of glucocorticoids; 2. Distant metastases including peritoneal carcinomatosis, liver metastases, distant lymph node metastases, and involvement of other organs; 3. Patients may undergo left, central, or total pancreatectomy other than PD; 4. Palliative surgery； 5. Patients with high operative risk, as defined by the American Society of Anesthesiologists (ASA), with a score ≥ 4; 6. Synchronous malignancy in other organs or second cancer requiring resection during the same procedure; 7. Pregnant and lactating women.