The main objective of this study is to prospectively follow the subjects included in "Descendance" cohort and to describe the occurrence of type 2 diabetes in non-diabetic subjects, which will allow us to iteratively update the "Descendance" Type 2 Diabetes risk prediction model.
High risk families will be prospectively follow in order to better understand the risk of transmission of type 2 diabetes from one generation to another. The cohort will also allow us to collect additional data on diabetic patients. The monitoring of the cohort will take place for at least 10 years with a follow-up of all participants every three years. To detect individuals who develop dysglycemia during the study, a glucose tolerance test (GTT) and HbA1c measurement will be conducted.
Study Type
OBSERVATIONAL
Enrollment
837
Oral Glucose Tolerance Test
HbA1c measurement
Follow-up questionnaire
Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Évry, France
Type 2 diabetes incidence in Descendance population
Presence of type 2 diabetes mellitus, on basis of self-reported (physician diagnosis) or diagnosed by OGTT and HbA1c
Time frame: 9years
Provide estimates of prevalence of diabetes and prediabetes in Descendance population
To estimate the prevalence of undiagnosed diabetes mellitus and pre-diabetes in Descendance population
Time frame: at baseline, 3-, 6- and 9-years follow-up
Study of interactions between risk factors on type 2 diabetes incidence
Self-administered questionnaire. "Descendance" specific questionnaire
Time frame: at baseline, 3-, 6- and 9-years follow-up
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