The Impact of Esmolol Administration on Postoperative Recovery

Aretaieion University Hospital70 enrolled

Overview

The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain

Contemporary anaesthesiology requires the quest of ways to restrict the use of opioids, which aim at the alleviation of severe postoperative and chronic pain. This is not only due to the side effects involved but also to the epidemic dimensions their use entails. Esmolol, an extremely short-acting cardioselective antagonist of β1 adrenergic receptors, is effectively used in order to attenuate the stress response and minimize undesirable perioperative hemodynamic changes. More specifically, esmolol has been used effectively to reduce pain during induction of anesthesia with propofol and treat tachycardia and hypertension during laryngoscopy. However, recent studies also highlight a possible antinociceptive and/or analgesic effect of esmolol. Therefore, The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Pain, Acute Pain, Postoperative Pain, Chronic Post-Surgical Esmolol Inguinal Hernia Repair Analgesia Nociceptive Pain

Interventions

Esmolol HydrochlorideDRUG

In the esmolol group, patients will receive a bolus dose of esmolol followed by a continuous infusion of esmolol intraoperatively

normal salineDRUG

In the placebo group, patients will receive a bolus dose of normal saline followed by a continuous infusion of normal saline intraoperatively

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients * American Society of Anesthesiologists (ASA) classification I-II * elective inguinal hernia repair Exclusion Criteria: * body mass index (BMI) \>35 kg/m2 * β-blocker administration preoperatively * systematic use of analgesic agents preoperatively * chronic pain syndromes preoperatively * neurological or psychiatric disease on treatment * pregnancy * severe hepatic or renal disease * history of cardiovascular diseases/ arrhythmias/ conduction abnormalities * hemodynamic instability * drug or alcohol abuse * language or communication barriers * lack of informed consent * bilateral inguinal hernia repair

Locations (1)

Evangelismos General Hospital

Athens, Greece

RECRUITING

Outcomes

Primary Outcomes

pain score 3 hours postoperatively

pain score by the use of Numeric Rating Scale (NRS) 3 hours postoperatively, ranging from 0 to 10, where 0 means "no pain" and 10 means "worst pain imaginable"

Time frame: 3 hours postoperatively

pain score 6 hours postoperatively

pain score by the use of Numeric Rating Scale (NRS) 6 hours postoperatively, ranging from 0 to 10, where 0 means "no pain" and 10 means "worst pain imaginable"

Time frame: 6 hours postoperatively

pain score 24 hours postoperatively

pain score by the use of Numeric Rating Scale (NRS) 24 hours postoperatively, ranging from 0 to 10, where 0 means "no pain" and 10 means "worst pain imaginable"

Time frame: 24 hours postoperatively

Central Contacts

Kassiani Theodoraki, PhD, DESA

CONTACT

+306974634162 ktheodoraki@hotmail.com

Vasiliki Samartzi

CONTACT

v.samartzi2@gmail.com

Data from ClinicalTrials.gov

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