Due to the advances made in the field of the imaging techniques and their common use, pancreatic cysts are more and more incidentally found. Pancreatic pseudocysts can be misdiagnosed as cystic neoplasms, in particular when there is no clinical history of acute or chronic pancreatitis. Pancreatic cystic neoplasms on the other hand are rare, but are difficult to diagnose accurately. Neutrophil gelatinase-associated lipocalin (NGAL) , interleukin 1 Beta (IL1beta) and High Mobility Group AT-Hook 2 (HmgA2) are molecules implicated in the process of inflammation and tumour development. The diagnostic value of their concentration in pancreatic cysts is not established yet. Study aim to asses the significance of NGAL,IL1Beta and HMGA2 concentration in cystic fluid obtained by endoscopic ultrasound (EUS) with EUS-guided fine-needle aspiration (EUS-FNA) and serum level for discriminating between inflammatory and non-inflammatory pancreatic cyst.
Study Type
OBSERVATIONAL
Enrollment
63
Patients with pancreatic cysts who underwent endoscopic ultrasound and endoscopic fine needle aspiration for diagnostic and therapeutic purpose. A sample of the cyst fluid and frozen serum was collected from the patients and stored at minus 80 degrees.
Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Cluj-Napoca, Romania
Role of the cyst fluid concentrations of the specific biomarkers for differentiation the pancreatic cystic lesions
Measurement the cyst fluid concentration of NGAL, IL1beta, HMGA2, expressed in nanograms/dl
Time frame: through study completion, an average of 1 year
The Correlation between cyst fluid concentration and serum level of the specific biomarkers
coefficient of correlation between the two values
Time frame: through study completion, an average of 1 year
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