Current evidence suggests a bidirectional association between periodontitis and diabetes. Periodontal therapy improves short term HbA1c levels and is safe to perform. Most studies are focused on type 2 Diabetes. Literature about the correlation between periodontitis and type 1 diabetes is scarce, since no randomized clinical trials have been performed. The objective of the present clinical investigation is to evaluate the effects of nonsurgical treatment of periodontal disease on glycemic variability in patients with type 1 diabetes (T1DM). The hypothesis is that nonsurgical periodontal therapy affects glycemic variability in terms of time spent in hyperglycemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
Non-surgical periodontal therapy according to the full-mouth debridement protocol.
Università degli Studi di Firenze
Florence, FI, Italy
Glycated hemoglobin (HbA1c)
Glycated hemoglobin (HbA1c) to evaluate glycemic variability measured as a percentage (%).
Time frame: 6 months after the non-surgical periodontal treatment
Standard Deviation (SD) of glycaemia
Standard Deviation: the spread of glucose readings around the average (mg/dl)
Time frame: 6 months after the non-surgical periodontal treatment
Glucose coefficient of variability (CV)
CV is a calculation: dividing the SD by the mean glucose and multiplying by 100 to get a percentage (%).
Time frame: 6 months after the non-surgical periodontal treatment
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