Efficacy and safety evaluation of tolvaptan in the treatment of patients with right heart failure caused by pulmonary arterial hypertension
The study is a prospective, single-center, randomized controlled trial. Specifically, the research focuses on patients with right heart failure due to PAH in the Pulmonary Vascular Ward of Fuwai Hospital. Within 12 hours of admission, subjects were randomly assigned to two groups using the central randomization method. The dose of tolvaptan (15 mg/d) is added to standard therapy (including diuretics) for subjects in group A. Traditional standard therapy (including diuretics) is used for subjects in group B. The treatment lasts for a total of seven days to assess the efficacy and safety of tolvaptan in the treatment of PAH-induced right heart failure. An informed consent form must be signed by each participant in our study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Within 12 hours of admission, subjects were randomly assigned to two groups using the central randomization method. For subjects in group A, tolvaptan (15 mg/d) is added to standard therapy (furosemide:20-40mg/d). The treatment lasts for a total of seven days to assess the efficacy and safety of tolvaptan in the treatment of PAH-induced right heart failure.
Within 12 hours of admission, traditional standard therapy (furosemide:20-40mg/d) is used for all subjects in our clinical trial. The treatment lasts for a total of seven days.
center of pulmonary vascular disease, Fuwai hospital
Beijing, China
RECRUITINGChanges in body weight( in kilograms ) of 7 days after medication or discharge day(one earlier).
Changes in body weight ( in kilograms ) of 7 days after medication or discharge day(one earlier).
Time frame: 7 days
Changes in urine volume (in milliliters)of 7 days after medication or discharge day(one earlier).
Changes in urine volume ( in milliliters ) of 7 days after medication or discharge day(one earlier).
Time frame: 7 days
Blood creatinine changes in renal function.
Blood creatinine changes in renal function.
Time frame: 7 days
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