First in Human Study to Compare Safety Between Intravenous Bolus Versus Infusion of ApTOLL

Inclusion Criteria: * Male or female (with no possibility to become pregnant (hysterectomized or menopausal women)) subjects who give their written consent to participate in the study. * Aged from 18 to 55. * No clinically significant organic or psychic conditions. * No clinically significant abnormalities in medical records and physical examination. * No clinically significant abnormalities in haematology, coagulation, biochemistry, serology and urinalysis . * No clinically significant abnormalities in vital signs and electrocardiogram. Exclusion Criteria: * Subjects affected by an organic or psychic condition. * Subjects who have received prescribed pharmacological treatment in the last 15 days or any kind of medication in the 48 hours prior to receiving the study medication * Subjects with body mass index (weight (kg)/height2 (m2)) outside the 18.5-30.0 range. * History of sensitivity to any drug. * Positive drug screening (for cannabis, opiates, cocaine and amphetamines). * Smoker. * Daily consumers of alcohol and/or acute alcohol poisoning in the last week. * Having donated blood in the last month before start of the study. * Participation in another study with administration of investigational drugs in the previous 3 months (if the study was conducted with drug substances marketed in Spain, a period of at least 1 month or 5 half lives, what is longer, will be considered). * Inability to follow the instructions or collaborate during the study.