This is a longitudinal observation of kidney function, immune system and gut microbiota before and 24 weeks after a live kidney transplantation conducted in donor and recipient pairs living in the same household. Outcome measures include kidney function, body composition, blood pressure, gut microbiome composition, metabolomics and immune cell states.
Study Type
OBSERVATIONAL
Enrollment
20
Experimental and Clinical Research Center
Berlin, Germany
RECRUITINGFecal microbiome taxonomy (Shannon-Index)
Measured by 16S amplicon sequencing
Time frame: Change from Baseline at 24 weeks
Functional capacity of gut microbiota
Measured by metagenome sequencing
Time frame: Change from Baseline at 24 weeks
Frequency of circulating T-cell subtypes
Measured by flow cytometry (%)
Time frame: Change from Baseline at 24 weeks
Serum tryptophan metabolites concentration
Measured by mass spectrometry
Time frame: Change from Baseline at 24 weeks
Serum short-chain fatty acid concentration
Measured by mass spectrometry
Time frame: Change from Baseline at 24 weeks
Fecal tryptophan metabolites concentration
Measured by mass spectrometry
Time frame: Change from Baseline at 24 weeks
Fecal short-chain fatty acid concentration
Measured by mass spectrometry
Time frame: Change from Baseline at 24 weeks
Office systolic blood pressure
Mean of five consecutive blood pressure measurements (mmHg)
Time frame: Change from Baseline at 24 weeks
Office diastolic blood pressure
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Mean of five consecutive blood pressure measurements (mmHg)
Time frame: Change from Baseline at 24 weeks
Body fat content
Measured by bioelectrical impedance analysis (%)
Time frame: Change from Baseline at 24 weeks
Fat free mass
Measured by bioelectrical impedance analysis (%)
Time frame: Change from Baseline at 24 weeks