The primary objective of the study is to evaluate the pharmacokinetics (PK) of AMG 510 administered as 8 x 120-mg tablets and as water dispersion in healthy participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
13
Tablets
Covance Clinical Research Unit, Inc 1341 W Mockingbird Ln, Ste 200E
Dallas, Texas, United States
Maximum Observed Plasma Concentration (Cmax) of AMG 510
Time frame: Day 1 and Day 4
Area Under the Plasma Concentration-time Curve (AUC) from Time Zero to Time of Last Quantifiable Concentration (AUClast) of AMG 510
Time frame: Day 1 and Day 4
Area Under the Plasma Concentration-time Curve from Time Zero to Infinity (AUCinf) of AMG 510
Time frame: Day 1 and Day 4
Number of Participants with an Adverse Event (AE)
An AE is any untoward medical occurrence in a clinical study participant irrespective of a causal relationship with the study treatment. Any clinically significant changes in clinical laboratory tests, 12-lead electrocardiograms and vital signs will be recorded as AEs .
Time frame: Day 1 to Day 6
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