Comparison Of Epidural Analgesia Techniques In Percutaneous Nephrolithotomy With Surgical Pleth Index

Ataturk University32 enrolled

Overview

Primary aim of this study is to evaluate affect of SPI guided antinociception on total intraoperative consumption of local aneshesics during analgesia. Secondary aims are defining time interval between LA administration and SPI value dropping under 50 and hemodynamy. Tertiary results are total mean local anesthesic consumption per hour, mean LA bolus number, total norepinephrine, ephedrine and atrophine consumption, mean intraoperative heart rate, mean arterial pressure, BIS and minimal alveolar concentration, percentage of intraoperative surgery time during which SPI\>50, time passed until first post operative analgesia need, time needed to be discharged from PACU after operation (evaluated via Aldrte score) and post operative side effects (nausea, vomiting, sedatition and piruritis)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Analgesia

Interventions

DURAL PUNCTURE EPIDURALPROCEDURE

group on whom dural puncture epidural technique used for intraoperative analgesia ( the DPL group; local anesthetics will be delivered via an epidural catheter placed after a dural pucture performed with the SPI guidance to provide intraoperative analgesia)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * aged 18-60 * ASA I-III * grade I unilateral PNL Exclusion Criteria: * BMI \> 40 kg/m2 * drug or alcohol abuse history in the last 6 mounts * chronic opoid usage or had chronic pain longer than 6 weeks * peripheral and central neurological disorders * preoperative hemodynamic disorders * irregular sinus rhythm and pace makers * diabetes, severe lung and major liver diseases with increasing biluribin * use of anti-muscarinics, α2-adrenergic agonists, β1-adrenergic agonists, anti arrhythmic; who used chronic psychoactive drugs in last 90 days * who are pregnant and breast feeding * not willing to participate * allergic or intolerant to any of the drugs in the study * procedures that take less than 2 hours

Outcomes

Primary Outcomes

consumption of local aneshesics

to evaluate affect of SPI guided antinociception on total intraoperative consumption of local aneshesics during analgesia

Time frame: intraoperative

Secondary Outcomes

time interval and SPI value dropping

defining time interval between LA administration and SPI value dropping under 50 and hemodynamy

Time frame: intraoperative

local anesthesic consumption

total mean local anesthesic consumption per hour, mean LA bolus number, total norepinephrine, ephedrine and atrophine consumption, mean intraoperative heart rate, mean arterial pressure, BIS and minimal alveolar concentration, percentage of intraoperative surgery time during which SPI\>50, time passed until first post operative analgesia need, time needed to be discharged from PACU after operation (evaluated via Aldrte score) and post operative side effects (nausea, vomiting, sedatition and piruritis)

Time frame: during the procedure/surgery and during 30 minutes of PACU stay

Comparison Of Epidural Analgesia Techniques In Percutaneous Nephrolithotomy With Surgical Pleth Index

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts