Several studies have shown an association between platelet function and stroke in patients undergoing carotid thromboendarterectomy (TEA). The present study will assess the correlation between platelet function evaluated by the impedance aggregometry and neurological events in patients undergoing carotid TEA.
Carotid thrombendarterectomy (TEA) is effective in preventing strokes which are a major cause of mortality and morbidity. Nevertheless, almost 10% of patients undergoing TEA develop a transient and/or permanent neurological injury. There is a growing body of evidence that platelet function is associated with perioperative neurological events in this setting, although the vast majority of patients undergoing carotid TEA are already on antiplatelet agents. The aim of the present study will be to assess the correlation between the platelet function evaluated by the impedance aggregometry (Multiplate ® Analyzer, Roche, Basel, Switzerland) and neurological events in patients undergoing carotid TEA.
Study Type
OBSERVATIONAL
Enrollment
386
1.6 ml of blood collected in hirudin-coated tubes before the surgery
Scientific Institute San Raffaele
Milan, Italy
RECRUITINGPlatelet function and neurological events
The platelet function will be evaluated by Multiple Electrode Aggregometry (Multiplate). It will be asses the correlation between thrombin receptor activator peptide 6 (TRAP test), adenosine-5'-diphosphate (ADP test) and arachidonic acid (ASPI test) expressed in arbitrary units area under the curve and neurological events in patients undergoing carotid thrombendarterectomy
Time frame: immediately before the surgery
TRAP, ADP and ASPI thresholds to predict neurological events
It will be find the best cut-off for TRAP, ADP and, ASPI in predicting neurological events
Time frame: immediately before the surgery
Occurence of thromboembolic neurological events
Time frame: within 1 month of patients' enrolled or before the hospital discharge
Occurrence of any complications
Occurrence of surgical and medical complications
Time frame: within 1 month of patients' enrolled or before the hospital discharge
6 months and 1 year mortality
Mortality at 6 months and 1 years after carotid surgery
Time frame: 6 months and 1 year
6 months and 1 year neurological events
Occurrence of neurological events after 6 months and 1 year after the procedure
Time frame: 6 months and 1 year
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