Effects of Intravenous Lidocaine on ED50, ED95 and NTI Values of Propofol Induced Unconsciousness

General Hospital of Ningxia Medical University100 enrolled

Overview

The effect of intravenous lidocaine on ED50 and ED95 of propofol, which causes unconsciousness, is unclear. In addition, it is not clear whether the depth of anesthesia induced by propofol changes when lidocaine is used in combination. Therefore, the purpose of this study was to study the effects of intravenous lidocaine on ED50, ED95 and NTI values of propofol induced unconsciousness .

Intravenous lidocaine has many advantages in perioperative period, in addition to reducing the amount of opioids and propofol, thus reducing the incidence of adverse reactions caused by them, it also has the effect on organ protection, can shorten the length of hospital stay, and promote postoperative recovery. The effect of intravenous lidocaine on ED50 and ED95 of propofol, which causes unconsciousness, is unclear. In addition, it is not clear whether the depth of anesthesia induced by propofol changes when lidocaine is used in combination. Therefore, the purpose of this study was to study the effects of intravenous lidocaine on ED50, ED95 and NTI values of propofol induced unconsciousness .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

General Anesthesia

Interventions

LidocaineDRUG

The experimental group was injected with lidocaine 1.5mg/kg, and propofol was pumped intravenously at 90s after lidocaine injection.The dose of propofol was further set according to groups. The heart rate, mean arterial pressure, pulse oxygen saturation and NTI values of subjects were recorded in tne basic state,during the 90s after lidocaine administration, 60s after propofol administration and consciousness loss.The control group simply replaced lidocaine with equal volume normal saline

Normal salineDRUG

Normal saline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. The informed consent is signed 2. Aged 18 to 65 years old 3. ASA is rated from I to II 4. Body mass index ranged from 18.5 to 24.9 kg/m2 Exclusion Criteria: 1. Unwilling to sign informed consent or refuse to participate in the study 2. Patients with serious arrhythmia and organic heart disease before surgery 3. Sedative and analgesic drugs were taken within 1 week before surgery 4. Lidocaine allergy 5. Patients with mental and neurological diseases 6. Patients with difficult airway 7. People with hearing impairment

Locations (2)

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

GuiMei Ji

Yinchuan, Ningxia, China

Outcomes

Primary Outcomes

The number of patients with loss of consciousness

Effects of intravenous lidocaine on ED50 and ED95 of propofol induced unconsciousness

Time frame: 6 hours

Secondary Outcomes

Effects of intravenous lidocaine on NTI values of propofol induced unconsciousness

The NTI values at T1,T2,T3 and T4 were recorded and statistically analyzed

Time frame: 6 hours

Central Contacts

GuiMei Ji, master

CONTACT

13619587243 1987780277@qq.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.