The Utility of Cell-free DNA Methylation Markers for Hepatocellular Carcinoma

National Taiwan University Hospital180 enrolled

Overview

The subjects of this study were patients with liver cancer diagnosed by physicians according to AASLD clinical criteria or pathological biopsy. Those who plan to receive systemic drug treatment for liver cancer in National Taiwan University Hospital include Nexavar, Lenvatinib, Avastin, Tecentriq, Strivarga, Cabometyx, Cyramza, Nivolunab, Pembrolizumab, and Yervoy. Weak and uncooperative patients were excluded from blood tests, which were performed with full informed consent for relevant tumor markers (AFP ,PIVKA-II and methylation analysis). The data are then counted and compared.

Study Type

OBSERVATIONAL

Enrollment

180

Conditions

Cell-free Methylation Markers

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients diagnosed with liver cancer by AASLD clinical criteria or pathological slides Patients planning to receive systemic drug therapy for liver cancer at National Taiwan University Hospital include Nexavar, Lenvatinib, Avastin, Tecentriq, Strivarga, Cabometyx, Cyramza, Nivolunab, Pembrolizumab, and Yevoy. 2. Over 20 years old. 3. In the case of informed consent, willing to sign the consent form of the subjects. Exclusion Criteria: 1. Patients who are weak and unable to cooperate with blood test. 2. Kidney dysfunction, serum creatinine greater than 1.5 x UNL (normal value) and no hemodialysis treatment, who are judged to be unwell for computed tomography or MRI contrast agent injection.

The Utility of Cell-free DNA Methylation Markers for Hepatocellular Carcinoma

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts