BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders

McGill University Health Centre/Research Institute of the McGill University Health Centre84 enrolled

Overview

This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.

The investigators will prospectively analyze OS-CMR data from patients with a generalized anxiety disorder from one site. The investigators will observe how an anxiety disorder affects the OS-CMR data. In a follow-up MRI scan, the investigators will look at the OS-CMR of a subgroup who have anxiety disorder and are also undertaking cognitive behavioural therapy to asses how and if this therapy affects the OS-CMR data.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Generalized Anxiety Disorder Oxygenation Sensitive CMR

Interventions

Cardiac MRIDIAGNOSTIC_TEST

The 4-minute breathing maneuver comprised of 2 minutes of normal breathing and 1-min hyperventilation (rate of 30 breaths per minute) followed by a maximal breath-hold. This technique is used in Oxygenation Sensitive CMR, a type of MRI, and will induce a vasoactive response visible in cardiac and cerebral MRI images

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Patient population: Age 18-55, * Confirmation of an anxiety disorder as identified by the PSWQ, * No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system (except anxiety and depression) * Non-smoker Healthy Volunteers: * Age 18-55 * No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system * Non-smoker Exclusion Criteria: * General MRI contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, pregnancy * History of significant neurological disease or illness that is not anxiety (e.g. Dementia, stroke) * Hemodynamically unstable conditions * Significant or uncontrolled arrhythmias * Severe pulmonary disease * Recent (\<90 days) myocardial infarction * Recent (\<90 days) surgery or coronary intervention * Consumption of caffeine (caffeinated beverages, coffee, tea, cocoa, chocolate) within 12h of the exam * Use of benzodiazepines or other short-acting anxiety medications (\<1 day)

Locations (1)

Emotional Health CBT Clinic

Montreal, Quebec, Canada

RECRUITING

Outcomes

Primary Outcomes

Change in Signal Intensity

Change in signal intensity between the baseline signal intensity and the signal intensity at 30 seconds of breath hold

Time frame: Baseline

Central Contacts

Mayssa Moukarzel

CONTACT

(514) 5530-7385 mayssa.moukarzel@mail.mcgill.ca

Elizabeth Konidis, Master

CONTACT

514-934-1934 elisavet.konidis@muhc.mcgill.ca

Data from ClinicalTrials.gov

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