Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study

ShangHai Ji Ai Genetics & IVF Institute692 enrolled

Overview

This retrospective cohort study aims to investigate the effects of recombinant human growth hormone (rh-GH) on the euploid status of preimplantation blastocysts in AMA patients. Infertile patients aged 38-46 years old were recruited for study if they fulfill the inclusion criteria and do not have the exclusion criteria. Treatment group: Women received growth hormone (GH) supplement during antagonist protocol for ovarian stimulation. Control group: Women received antagonist protocol for ovarian stimulation. The primary outcome is the euploidy rate of blastocysts per stimulation cycle and per testing cycle.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

692

Conditions

Growth Hormone Advanced Maternal Age PGT-A

Interventions

Eligibility

Sex: FEMALEMin age: 38 YearsMax age: 46 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 38-46; BMI 18.5-24.0kg/m2; intended to undergo PGT-A; GnRH Antagonist protocol for ovarian stimulation; normal semen analysis for the male partner Exclusion Criteria: * Endometriosis grade 3 or higher, untreat hydrosalpinx; * Women with a uterine cavity abnormality, such as a uterine congenital malformation (uterus uni-cornate, bicornate, or duplex); * Untreated uterine septum, adenomyosis, submucous myoma, or endo-metrial polyp(s) * Women who are indicated and planned to undergo PGT-SR (Preimplantation genetic testing for structural rearrangement) or PGT-M (Preimplantation genetic testing for monogenic disorder), for example, parental abnormal karyo-type or diagnosed with monogenic disease; * Women who received other supplement drugs during ovarian stimulation

Outcomes

Primary Outcomes

Proportion of cycles which obtained euploid blastocysts

Number of cycles with at least 1 euploid blastocyst divided by the total number of stimulation cycles in a cohort

Time frame: 1 month after oocyte retrieval

Secondary Outcomes

Euploid blastocyst rate per cohort

Total number of euploid blastocyst in a cohort/total number of biopsied embryos in the same cohort

Time frame: 1 month after oocyte retrieval

Euploidy rate per cycle

Euploidy rate of blastocysts, calculated per stimulation cycle and per testing cycle

Time frame: 1 month after oocyte retrieval

Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes