Neurobiology has improved the integrative understanding of brain development. With digital technologies, digital (bio)markers would be relevant variables for a better understanding of the heterogeneity of cognitive and behavioral functioning in developing children. However, the dominant statistical approach of group comparison tends to ignore intragroup variability. Applying high-dimensional data sets through multivariate methods and then combining their scores via predictive model learning algorithms would allow the identification of subtypes. Thus, EPIDIA4KIDS wants to understand the brain functioning of children aged 7 to 12 years old from heterogeneous data sources collected from a touchscreen tablet.
The overall objective of the EPIDIA4KIDS study is to understand brain functioning in children aged 7 to 12 years from heterogeneous digital data collected with a touch tablet. The investigators want to develop a digital e-screening, similarly to a blood test result, for cognitive, emotional and behavioral performances in children from 7 to 12 years old, resulting from a multimodal and multi-stream analysis generated by an artificial intelligence algorithm. The main aims are therefore to: * Develop a normative base of cognitive, emotional and, behavioral performances with children aged 7 to 12 years old using our digital tool. * Examine the validity of our e-assessment by comparing the generated results to those obtained with standard measures of convergent validity.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
736
Children will be playing on a series of games with a touch screen tablet while video and digit trajectories data will be collected from this mobile device to analyze eye-, face-, sound-recognition.
Electrical recordings and measurements - A mobile EEG headset will be used during the visit - 30 min
Association la Busserine
Marseille, Provence Alpes Cotes d'Azur, France
NOT_YET_RECRUITINGO-Kidia
Gardanne, Provence-Alpes-Côte d'Azur Region, France
RECRUITINGCreate a Normative Database for emotional, behavioral and cognitive performance
Measure number of criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet Total errors, Number of errors in total, False responses
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Measure number of criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet False responses
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Measure number of criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet Number of responses other than omission
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Measure number of criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet Hits/Accuracy, Number of correct responses, Hits of correct responses
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Measure number of criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet Standard deviation of the 3 standard errors calculated for each task block
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Measure number of criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet Order of combination of responses
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Time criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of typically developing children when playing with the O-Kidia battery on a touchscreen tablet Hits of Reaction time (RT), Median of reaction times for correct responses, Hits RT SE Standard error of Hits RT, Hits RT block change
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Time criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of typically developing children when playing with the O-Kidia battery on a touchscreen tablet Slope of change in RT between blocks, Slope of change in RT standard errors between blocks
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Time criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of typically developing children when playing with the O-Kidia battery on a touchscreen tablet SE variability Standard deviation of the 3 standard errors calculated for each task block
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Time criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of typically developing children when playing with the O-Kidia battery on a touchscreen tablet Order of combination of responses by reaction time
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Eye-movement criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet \- Eye-tracking associated with O-Kidia battery: Number of saccade (pro/anti-), Number of blinks
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Eye-movement for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet \- Eye-tracking associated with O-Kidia battery: near-point convergence, Near-point contact point
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Eye-movement criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet \- Eye-tracking associated with O-Kidia battery: amplitude, direction, direction interval,
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Time of eye-movement criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet \- Eye-tracking associated with O-Kidia battery: reaction time, fixation, time interval
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Digit-movement criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet \- Digit-tracking associated with O-Kidia battery : direction, cumulated distance, distance to the proper trajectory
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Time of digit-movement criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet \- Digit-tracking associated with O-Kidia battery : exploration time, time to the proper trajectory
Time frame: 24 months
Create a Normative Database for emotional, behavioral and cognitive performance
Velocity of digit-movement criteria for motor skills, emotions, cognition and behavior, and therefore a neurodevelopmental presentation of developing children when playing with the O-Kidia battery on a touchscreen tablet
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- Accuracy measures are :Total errors, Number of errors in total
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- False responses, Number of responses other than omission
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- Number of correct responses, Hits of correct responses
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- SE variability Standard deviation of the 3 standard errors calculated for each task block
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- Order of combination of responses
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- Reaction time (RT) median for correct responses, Hits RT SE Standard error of Hits RT, Hits RT block change
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- Slope of change in RT between blocks, Slope of change in RT standard errors between blocks
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : WISC-V subtests, including Verbal concept, Fluid Reasoning scale, Working Memory measures, Processing Speed abilities \- SE variability Standard deviation of the 3 standard errors calculated for each task block, Order of combination of responses by reaction time
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Event planification abilities, the Tower of London Determination of performance at the test of the Tower of London coupled with eye-tracking. * Tower of London: analysed variables are: Number of problems solved (maximum duration is one minute) Failure if three successive problems are unsolved Types of error : systematic rule violation, back-and-forth Percentage of problems solved with the execution (minimal) number of moves. * Hits/Accuracy Number of correct responses The higher score is the better outcome.
Time frame: 18 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Event planification abilities, the Tower of London Time for the performance at the test of the Tower of London coupled with eye-tracking. * Duration for planification and execution * Reaction Time, Total errors * Hits RT Median of reaction times for correct responses, Hits RT SE Standard error of Hits RT
Time frame: 18 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Children Behavior Check List (short version, 32 items) 32 items rated on a 3-point Likert-type scale, ranging from "never" (0) to "very often" (3) for the anxiety scale. The higher score is the worse outcome.
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Children Behavior Check List (short version, 32 items) 32 items rated on a 3-point Likert-type scale, ranging from "never" (0) to "very often" (3) for the evitant/depression scale. The higher score is the worse outcome.
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Children Behavior Check List (short version, 32 items) 32 items rated on a 3-point Likert-type scale, ranging from "never" (0) to "very often" (3) for the social problem scale. The higher score is the worse outcome.
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Behavioral assessment of executive function scoring (BRIEF, 72 items) 72 items rated on a 3-point Likert-type scale, ranging from "never" (1) to "often" (3).The clinical scale gives a well-rounded picture of the behavior of the child or adolescent being rated.
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : (Keith Conners-3, 108 items) -108-items rated on a 4-point Likert-type scale, ranging from "never" (0) to "often" (3) to give insight into ADHD assessment as well as comorbid disorders such as Oppositional Defiant Disorder and Conduct Disorder. The higher score is the worse outcome
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Autism Quotient List version scoring (10 items) -10-items rated on a 4-point Likert-type scale, ranging from "Strongly agree" (1) to "definitely disagree" (3). Only one point can be awarded for each question. Give 1 point for "Strongly agree" or "Definitely disagree " for questions 1, 5, 7, and 10. Award 1 point for "Strongly Disagree" or "Strongly Disagree" for each of questions 2, 3, 4, 6, 8 and 9. If the person scores 6 or higher, he or she probably has social difficulties requiring referral for a specialized diagnostic assessment.
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : QTAC scoring, coordination acquisition disorder (15 items) 15-items rated on a 5-point Likert-type scale, ranging from "not alike" (1) to "extremyly alike disagree" (5). The higher the scores the higher coordination acquisition disorder is suspected.
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Inattention and Hyperactivity-Impulsivity components with the ADHD-Rating Scale (18 items) \- Measure of number of criteria for inattention, hyperactivity-impulsivity and therefore clinical presentation of ADHD (Predominant Inattentive, Predominant Hyperactive-Impulsive, Combined )
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Inattention and Hyperactivity-Impulsivity components with the ADHD-Rating Scale (18 items) \- ADHD Rating Scale: 9 inattention items and 9 hyperactivity-impulsivity items rated on a 0-3 scale (range 0-27), therefore the total score is on a 0-54 range. The higher the scores the higher the inattention and hyperactivity-impulsivity
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Perseverance \- the Grit-Scale for Children (GSCA, 12 items), items rated on a 1-5 scale, therefore the total score is on a 0-60 range, then divided by 12. The maximum score on this scale is 5 (extremely gritty), and the lowest scale on this scale is 1 (not at all gritty).
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Motivation \- the School Motivation Questionnaire (SMQ, 10 min), 30 items on a Five-point Likert-type scale, ranging from "never" (1) to "very often" (5). The SMQ maximum total score is 150 and the minimum is 30 with solid loading scores: Self-Determination (SD), Self-Efficacy (SE), Intrinsic Motivation (IM), and Grade Motivation (GM)
Time frame: 24 months
Convergence validity for the O-Kidia battery
Describe the subgroup and compare it to pattern of comorbidities : Sleep quality (Pittsburgh Sleep Quality Index, 11 items) \- The PSQI consists of 11 self-report questions that combine to give 7 "components" of the overall score, with each component receiving a score from 0 to 3. In all cases, a score of 0 indicates no difficulty while a score of 3 indicates severe difficulty. The 7 components of the score are added together to give an overall score ranging from 0 to 21 points, with 0 indicating no difficulty and 21 indicating major difficulty. A global score is the addition of these 7 components.
Time frame: 24 months
Description of participants' characteristics
Measure of demographics with age
Time frame: 24 months
Description of participants' characteristics
Measure of language spoken
Time frame: 24 months
Description of participants' characteristics
Measure of family structure, school, medical history with questionnaires
Time frame: 24 months
Description of participants' characteristics
Measure of manual laterality, Edinburgh handedness, short version, to indicate manual laterality from 4 items rated on a five-point Likert-type scale, ranging from "always right" to "always left", scoring from +100 to -100.
Time frame: 24 months
Description of participants' characteristics
Socioeconomic status as measure INSEE index
Time frame: 24 months
mobile EEG biomarkers
P300 wave amplitude and latency - Quantitative electroencephalography (qEEG) will be recorded during a resting state, Elicitation of evoked potentials (ERP) will use the O-Kidia battery to elicit components associated with attention, working memory, stress, or anxiety
Time frame: 24 months
mobile EEG biomarkers
P1, N1, P2, N2 and P3 waves, amplitudes and latencies - Elicitation of evoked potentials (ERP) will use the O-Kidia battery to elicit components associated with attention, stress, or anxiety
Time frame: 24 months
mobile EEG biomarkers
N170 waves, amplitudes and latencies as measures of episodic memory
Time frame: 24 months
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mobile EEG biomarkers
Alpha-, theta, beta waves and their ratios as a measures of ADHD assessments.
Time frame: 24 months
UX/UI feasibility
Questionnaire (10-items) assessing the usability (UX/UI) for children, on a five-point likert type scale ranging 0 to 50 points, higher scores meaning better outcome.
Time frame: 12 months
Test-retrests for the O-Games battery
Significant changes of either or both scores at T2 compared with baseline (repeated testing), higher scores meaning better outcome.
Time frame: 24 months