DYG Versus Cetrorelix in Oocyte Donation

Clinica de la Mujer Medicina Reproductiva, Chile202 enrolled

Overview

Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm. The OD cycles were triggered with triptoreline acetate and the trigger criterion was ≥3 follicles of diameter \>18mm.

Study Type

OBSERVATIONAL

Enrollment

202

Conditions

Infertility, Female Fertility Disorders

Interventions

DydrogesteroneDRUG

progestin primed ovarian stimulation

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Oocyte donors between 21 and 30 years old, with regular menstrual cycles (24-35 d) and a body mass index (BMI) between 18 and 28 kg/m2 without any relevant personal or family history Exclusion Criteria: * AMH less than 3 ng/dL * A positive screening for sexually transmitted diseases

Outcomes

Primary Outcomes

Live Birth Rate per transfer

Time frame: 40 weeks after ET

Clinical pregnancy per transfer

Time frame: 12 weeks after ET

Miscarriage rate

Time frame: 12 weeks after ET

Secondary Outcomes

Number of oocytes retrieved

Time frame: at time of oocyte retrieval

Number of mature oocytes

Time frame: 1 day after IVF

Number of fertilized oocytes

Time frame: 1 day after IVF

Number of blastocists

Time frame: 5-6 days after OPU

Data from ClinicalTrials.gov

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