Prevalence and Genetic Alternation of Autoimmune Polyglandular Syndrome Type II in Taiwan

National Taiwan University Hospital650 enrolled

Overview

Autoimmune polyendocrine syndrome (APS) is an autoimmune disease involving at least two endocrine organ. It is classified into type I and type II diseases. Among them, APS type II is more common. It is diagnosed when two of the three following diseases are diagnosed in the same patient, including type 1 diabetes mellitus, autoimmune thyroid disease, and primary adrenal insufficiency. In this study, we will observe the epidemiology, clinical characteristics, and genetic variants of APS II in Taiwan.

Study Type

OBSERVATIONAL

Enrollment

650

Conditions

Autoimmune Polyendocrine Syndrome Type II

Interventions

no interventionOTHER

No intervention, only observation

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients visited NTUH during 2006-2021, and had at least two of the three diseases: type 1 DM, primary adrenal insufficiency, and autoimmune thyroid disease. Exclusion Criteria: * Patients aged less than 20 years old

Outcomes

Primary Outcomes

Rates of endocrine organs involved

We will observe the rate of each endocrine organ involved, including adrenal gland, thyroid, and pancreas

Time frame: 2022/1/1 ~ 2026/12/31